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Table 3 Effects of cumulative doses of risperidone on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M.

From: Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats

  Urodynamic parameters EUS EMG parameters
Dose BC (ml) MV (ml) RV (%) PT PP CT (sec) ET (sec) HFO Phase 1 Phase 2 Phase 3 Burst
(mg/kg)     (mm Hg) (mm Hg)    (mm Hg) (%) (%) (%) Amp.(%)
Control 0.35 0.27 21 2.4 11.5 18.5 3.6 1.6 100 100 100 100
  (±0.097) (±0.072) (±5.6) (±0.62) (±0.95) (±1.43) (±0.83) (±0.19)     
0.01 0.38 0.17 47 ** 2.8 11.7 19.3 2.7 1.3 100 76 91 (±8.4) 105
  (±0.080) (±0.033) (±9.2) (±0.72) (±1.0) (±1.97) (±0.49) (±0.12) (±11.5) (±14.7)   (±3.4)
0.1 0.38 0.10 * 70 ** 3.4 11.7 19.4 1.5 ** 1.0 * 84 50 * 78 * 80
  (±0.055) (±0.019) (±7.8) (±0.44) (±0.82) (±1.94) (±0.34) (±0.22) (±11.7) (±12.3) (±10.1) (±19.6)
1 0.40 0.12 ** 67 ** 5.0 * 12.4 18.6 1.4 ** 0.9 ** 74 47 * 68 ** 76
  (±0.060) (±0.016) (±5.8) (±1.02) (±1.16) (±2.6) (±0.35) (±0.18) (±13.2) (±12.7) (±8.0) (±14.0)
10 0.54 0.19 60 ** 5.8 ** 13.7 ** 17.2 2.2 * 1.1 * 81 71 (±22) 73 ** 84
  (±0.080) (±0.036) (±7.7) (±1.02) (±1.34) (±0.96) (±0.46) (±0.22) (±15.2)   (±9.0) (±14.6)
  *            
  1. * p < 0.05; ** p < 0.01