Figure 2From: Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized ratsRepresentative traces of the effects of cumulative doses of risperidone on the CMG and external urethral sphincter EMG of anesthetized rats (n = 7). A & B) CMG after saline administration. C & D) 0.01 mg/kg of risperidone did not affect expulsion time although residual volume was significantly increased (Table 3; Fig 3C). E & F) At 0.1 mg/kg, risperidione caused a reduction in the amplitude of the HFO and the expulsion time. Larger doses of risperidone (1 mg/kg, G & H; 10 mg/kg, I & J) continued to depress the expulsion time and reduced the external urethral sphincter EMG. Note that the HFO were not abolished, unlike the results obtained with olanzapine. Calibration bar: A,C,E,G,I = 1 min; B,D,F,H,J = 1 sec.Back to article page