Figure 7
Effect of PMA on insulin secretion in response to glucose stimulation of rat isolated islets. The rates of insulin secretion from rat islets were shown. Islets were separated into two groups, treated and untreated with BIM. The rates of insulin secretion were measured with glucose at 5.5 mM and 16.6 mM in the extracellular solution, respectively. 80 nM PMA or 80 nM PM plus 1 μM BIM was compared with the value obtained in islets without any treatment. Mean values of 5–15 experiments are shown. Vertical bars indicate SE. *P < 0.05. All measurements were performed at 37°C.