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Figure 3 | BMC Pharmacology

Figure 3

From: Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels

Figure 3

PMA induces KATP activity recorded in the cell-attached configuration. Single channel recordings in the cell-attached configuration are shown. The pipette potential (Vp) was held at 0 mV. Application of 80 nM PMA to the bath increased channel opening. Tolbutamide (0.5 mM), applied to the bath during PMA, completely inhibited channel activity, suggesting that PMA increased KATP activity.

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BMC Pharmacology

ISSN: 1471-2210