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Table 1 Effect of GABA Ligands on Vertebral Arch Width

From: The effect of GABA receptor ligands in experimental spina bifida occulta

Drug Number of Litters Mean # Embryos per Litter Mean Arch Width (microns) S.D. Sig. (p=)
Normal Saline 15 8.67 71.5 16.4 N/A
Valproic Acid 15 7.20 90.5 19.5 .0005
Muscimol 1 3 10.67 89.3 11.9 .09
Muscimol 2 10 9.9 93.9 8.6 .0003
Muscimol 4 9 11.44 87.25 14.7 .01
Bicuculine 0.5 4 5.25 88.2 9.0 .04
Bicuculine 1 5 5.80 90.5 15.5 .01
Bicuculine 2 3 5.67 82.8 9.0 NS
Baclofen 15 14 8.64 73.6 17.3 NS
Baclofen 30 7 10.43 86.0 13.0 .03
Baclofen 60 10 10.10 75.5 14.6 NS
Hydroxysaclofen 1 10 9.80 61.5 9.6 .09
Hydroxysaclofen 3 9 5.00 50.8 16.2 .001
Hydroxysaclofen 5 9 8.56 59.15 3.15 .05