Table 1 Effect of GABA Ligands on Vertebral Arch Width
From: The effect of GABA receptor ligands in experimental spina bifida occulta
Drug | Number of Litters | Mean # Embryos per Litter | Mean Arch Width (microns) | S.D. | Sig. (p=) |
|---|---|---|---|---|---|
Normal Saline | 15 | 8.67 | 71.5 | 16.4 | N/A |
Valproic Acid | 15 | 7.20 | 90.5 | 19.5 | .0005 |
Muscimol 1 | 3 | 10.67 | 89.3 | 11.9 | .09 |
Muscimol 2 | 10 | 9.9 | 93.9 | 8.6 | .0003 |
Muscimol 4 | 9 | 11.44 | 87.25 | 14.7 | .01 |
Bicuculine 0.5 | 4 | 5.25 | 88.2 | 9.0 | .04 |
Bicuculine 1 | 5 | 5.80 | 90.5 | 15.5 | .01 |
Bicuculine 2 | 3 | 5.67 | 82.8 | 9.0 | NS |
Baclofen 15 | 14 | 8.64 | 73.6 | 17.3 | NS |
Baclofen 30 | 7 | 10.43 | 86.0 | 13.0 | .03 |
Baclofen 60 | 10 | 10.10 | 75.5 | 14.6 | NS |
Hydroxysaclofen 1 | 10 | 9.80 | 61.5 | 9.6 | .09 |
Hydroxysaclofen 3 | 9 | 5.00 | 50.8 | 16.2 | .001 |
Hydroxysaclofen 5 | 9 | 8.56 | 59.15 | 3.15 | .05 |