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Table 4 Theoretical CNBr fragments of the α1-subunit of the sGC. MW: molecular weight; AA: amino acid; the several amino acids are shown in the one-letter-code.

From: NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272

CNBr fragment MW [kDa] AA number AA position in the α1 subunit Sequence from the N-terminus
CNBr-1 24 215 21–235 APGQVPTEPIEE...
CNBr -2 6.2 54 236–290 PPCFRSECTEFV...
CNBr -3 5.5 47 291–338 LDRDLAILQLG...
CNBr -4 0.2 2 339–340 TM
CNBr -5 0.3 3 341–343 LNM
CNBr -6 2.5 19 344–363 QFVIRVRRWDNL...
CNBr -7 0.6 6 364–369 DLKGQM
CNBr -8 12.5 111 370–481 IYIVESSAILFLG...
CNBr -9 2.4 22 482–504 LFSDIVGFTAICS...
CNBr -10 5.2 46 505–551 LNALYTRFDQQ...
CNBr -11 0.4 4 552–555 ALKM
CNBr -12 0.1 1 556 M
CNBr -13 0.8 7 557–563 ELSNEVM
CNBr -14 0.9 9 564–572 SPHGEPIKM
CNBr -15 1.8 17 573–590 RIGLHSGSVFAG...
CNBr -16 11.2 99 591–690 PRYCLFGNNVT...