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Table 2 Specific activities of individual CYP enzymes (pmol product/nmolP450/min)

From: Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs

Sample CYP3A CYP2A CYP2C
Liver microsomal fraction 2193 ± 523 210 ± 70 136 ± 31
CYP – containing fractions 3716 ± 428 423 ± 148 n.d.
  1. The nifedipine oxidase (CYP3A), coumarin 7-hydroxylation (CYP2A) and tolbutamide methyl-hydroxylation activities in microsomes and fractions containing partially purified CYP enzymes were determined as indicated in Materials and Methods, n.d., not determined.