Skip to main content

Table 2 Specific activities of individual CYP enzymes (pmol product/nmolP450/min)

From: Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs

Sample

CYP3A

CYP2A

CYP2C

Liver microsomal fraction

2193 ± 523

210 ± 70

136 ± 31

CYP – containing fractions

3716 ± 428

423 ± 148

n.d.

  1. The nifedipine oxidase (CYP3A), coumarin 7-hydroxylation (CYP2A) and tolbutamide methyl-hydroxylation activities in microsomes and fractions containing partially purified CYP enzymes were determined as indicated in Materials and Methods, n.d., not determined.
Back to article page

BMC Pharmacology

ISSN: 1471-2210