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Figure 3 | BMC Pharmacology

Figure 3

From: Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death

Figure 3

Activation of c-jun by 25-OH-cholesterol. Cells were treated with 10 μM 25-OH-cholesterol or 10 μM 7-β-OH-cholesterol for 12 hours, then processed for Western blot analyses. Antibodies against c-jun, phospho-c-jun (at serine 63) and ERK 1/2 were used in this set of experiments. Concurrent electrophoresis procedures were performed for each antibody. Results indicated that c-jun activation, i.e., phosphorylation of c-jun, was associated with the toxicity of 25-OH-cholesterol.

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