Volume 7 Supplement 1

3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Dresden, Germany15-17 June 2007

Page 1 of 3

Characterization of tandem GAF domains of phosphodiesterases

Authors: Joachim E Schultz, Karina Hofbauer and Marco Gross-Langenhoff

Citation: BMC Pharmacology 2007 7(Suppl 1):S1

Content type: Oral presentation Published on: 25 July 2007
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cGMP signaling pathway is involved in Leyding cell stress response

Authors: Silvana Andric, Natasa Stojkov, Marija Janjic, Stanko Stojilkovic and Tatjana Kostic

Citation: BMC Pharmacology 2007 7(Suppl 1):P1

Content type: Poster presentation Published on: 25 July 2007
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Therapeutic potential of soluble guanylate cyclase agonists in pulmonary hypertension

Authors: Oleg V Evgenov, Daniel S Kohane and Warren M Zapol

Citation: BMC Pharmacology 2007 7(Suppl 1):S2

Content type: Oral presentation Published on: 25 July 2007
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Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension?

Authors: Reshma S Baliga, Lan Zhao, Martin R Wilkins, Raymond J MacAllister and Adrian J Hobbs

Citation: BMC Pharmacology 2007 7(Suppl 1):P2

Content type: Poster presentation Published on: 25 July 2007
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sGC stimulators in experimental pulmonary hypertension

Authors: Ralph Theo Schermuly, Hossein Ardeschir Ghofrani and Friedrich Grimminger

Citation: BMC Pharmacology 2007 7(Suppl 1):S3

Content type: Oral presentation Published on: 25 July 2007
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LPS-induced down-regulation of NO-sensitive guanylyl cyclase in astrocytes occurs by proteasomal degradation in nuclear bodies

Authors: María Antonia Baltrons, Paula Pifarré, María Teresa Berciano, Miguel Lafarga and Agustina García

Citation: BMC Pharmacology 2007 7(Suppl 1):P3

Content type: Poster presentation Published on: 25 July 2007
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Role of the sGC activator ataciguat sodium (HMR1766) in cardiovascular disease

Authors: Martin van Eickels, Sven Wassmann, Andreas Schäfer, Johann Bauersachs, Hartmut Strobel and Hartmut Rütten

Citation: BMC Pharmacology 2007 7(Suppl 1):S4

Content type: Oral presentation Published on: 25 July 2007
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Relaxant effect of BAY 41–2272 in the rabbit isolated detrusor smooth muscle (DSM): involvement of cGMP-independent mechanisms

Authors: Fernando R Báu, Cleber E Teixeira, Gilberto De Nucci and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P4

Content type: Poster presentation Published on: 25 July 2007
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Oxidised sGC: a novel therapeutic target in the vasculature

Authors: Barbara Kemp-Harper, Jonathan Luk, Joanne Favaloro, Johannes-Peter Stasch and Harald Schmidt

Citation: BMC Pharmacology 2007 7(Suppl 1):S5

Content type: Oral presentation Published on: 25 July 2007
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Daily treatment with sildenafil, an inhibitor of cGMP-dependent phosphodiesterase, normalizes the exaggerated hemodynamic response to norepinephrine in fructose-fed rats

Authors: Delphine Behr-Roussel, Alexandra Oudot, Sandrine Compagnie, Diana Gorny, Olivier Le Coz, Jaques Bernabé, Chris Wayman, Laurent Alexandre and Francois Giuliano

Citation: BMC Pharmacology 2007 7(Suppl 1):P5

Content type: Poster presentation Published on: 25 July 2007
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Molecular modulators of cardiac stress targeted by PDE5 inhibition

Authors: Eiki Takimoto, Takayoshi Nagayama, Susan Vahebi, Carlo Gabrielli Tocchetti, Elizabeth Ketner, Diego Belardi, Hunter Champion, Michael Mendelsohn and David A Kass

Citation: BMC Pharmacology 2007 7(Suppl 1):S6

Content type: Oral presentation Published on: 25 July 2007
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Selective activation of hippocampal guanylyl cyclase by a novel NO mimetic nitrate ester

Authors: Brian Bennett, James Reynolds and Greg Thatcher

Citation: BMC Pharmacology 2007 7(Suppl 1):P6

Content type: Poster presentation Published on: 25 July 2007
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Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension

Authors: Adrian J Hobbs

Citation: BMC Pharmacology 2007 7(Suppl 1):S7

Content type: Oral presentation Published on: 25 July 2007
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Activation of soluble guanylate cyclase in the presence of purified human aldehyde dehydrogenases

Authors: Matteo Beretta, Alexander Kollau, Michael Russwurm, Doris Koesling, Wing Ming Keung, Kurt Schmidt and Bernd Mayer

Citation: BMC Pharmacology 2007 7(Suppl 1):P7

Content type: Poster presentation Published on: 25 July 2007
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BAY 63–2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile, improves cardiopulmonary haemodynamics and has therapeutic potential in pulmonary hypertension

Authors: Hossein Ardeschir Ghofrani, Gerrit Weimann, Reiner Frey, Robert Voswinckel, Melanie Thamm, Desire Bölkow, Norbert Weissmann, Wolfgang Mück, Sigrun Unger, Georg Wensing, Ralph Theo Schermuly and Friedrich Grimminger

Citation: BMC Pharmacology 2007 7(Suppl 1):S8

Content type: Oral presentation Published on: 25 July 2007
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Relaxation of vascular smooth muscle by the cGMP-kinase substrate IRAG

Authors: Dominik Bernhard, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology 2007 7(Suppl 1):P8

Content type: Poster presentation Published on: 25 July 2007
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BAY 58–2667, a soluble guanylate cyclase activator, improves cardiopulmonary haemodynamics in acute decompensated heart failure and has a favourable safety profile

Authors: Harald Lapp, Veselin Mitrovic, Norbert Franz, Hubertus Heuer, Michael Buerke, Judith Wolfertz, Wolfgang Mück, Sigrun Unger, Georg Wensing and Reiner Frey

Citation: BMC Pharmacology 2007 7(Suppl 1):S9

Content type: Oral presentation Published on: 25 July 2007
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Targeting heme-oxidized soluble guanylate cyclase with BAY 58-2667 in experimental heart failure

Authors: Guido Boerrigter, Lisa C Costello-Boerrigter, Alessandro Cataliotti, Harald Lapp, Johannes-Peter Stasch and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P9

Content type: Poster presentation Published on: 25 July 2007
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The emerging role of PDE5 inhibition in heart failure

Authors: Gregory D Lewis, Jordan Shin, David M Systrom, Kenneth D Bloch and Marc J Semigran

Citation: BMC Pharmacology 2007 7(Suppl 1):S10

Content type: Oral presentation Published on: 25 July 2007
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Opposite effects of cGMP-dependent protein kinase on cGMP production by soluble and particular guanylyl cyclase in adult ventricular myocytes

Authors: Liliana Castro and Rodolphe Fischmeister

Citation: BMC Pharmacology 2007 7(Suppl 1):P10

Content type: Poster presentation Published on: 25 July 2007
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Clinical trials with urodilatin in patients with acute decompensated heart failure

Authors: Veselin Mitrovic

Citation: BMC Pharmacology 2007 7(Suppl 1):S11

Content type: Oral presentation Published on: 25 July 2007
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Run training ameliorates the established erectile dysfunction in rats under long-term nitric oxide (NO) blockade

Authors: Mário A Claudino, Juliana S Baracat, Enilton A Camargo, Fernanda BM Priviero, Cleber E Teixeira, Gilberto de Nucci, Angelina Zanesco and Edson Antunes

Citation: BMC Pharmacology 2007 7(Suppl 1):P11

Content type: Poster presentation Published on: 25 July 2007
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The NO-cGMP axis in endothelial ischemia and ischemic preconditioning

Authors: Tommaso Gori and John Parker

Citation: BMC Pharmacology 2007 7(Suppl 1):S12

Content type: Oral presentation Published on: 25 July 2007
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Coadministration of B-type natriuretic peptide and the vasopressin-2 receptor antagonist tolvaptan: a novel physiologic strategy to enhance water and sodium excretion without adversely affecting renal or neurohumoral function in experimental congestive heart failure

Authors: Lisa C Costello-Boerrigter, Guido Boerrigter, Gail J Harty and John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):P12

Content type: Poster presentation Published on: 25 July 2007
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Restoration of learning in hepatic encephalopathy by pharmacological manipulation of cGMP levels in brain

Authors: Vicente Felipo

Citation: BMC Pharmacology 2007 7(Suppl 1):S13

Content type: Oral presentation Published on: 25 July 2007
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Pharmacological characterization of the novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum

Authors: Gilberto De Nucci, Raquel Lorenzetti, Cristina E Okuyama, Juliana S Baracat, José L Donato, Edson Antunes and Cleber E Teixeira

Citation: BMC Pharmacology 2007 7(Suppl 1):P13

Content type: Poster presentation Published on: 25 July 2007
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Modulating cGMP in heart failure

Authors: John C Burnett Jr

Citation: BMC Pharmacology 2007 7(Suppl 1):S14

Content type: Oral presentation Published on: 25 July 2007
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Analysis of smooth muscle function in IRAG knockout mice

Authors: Matthias M Desch, Katja Sigl, Beate Spiessberger, Dominik Bernhard, Angela Jochim, Jörg W Wegener, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology 2007 7(Suppl 1):P14

Content type: Poster presentation Published on: 25 July 2007
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Analysis of mice with genetic modifications of PKG I

Authors: Franz Hofmann, Robert Lukowski, Dominik Bernhard, Pascal Weinmeister, Silke Weber, Susanne Feil, Jens Schlossmann, Jörg W Wegener and Robert Feil

Citation: BMC Pharmacology 2007 7(Suppl 1):S15

Content type: Oral presentation Published on: 25 July 2007
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NO-induced motility effects in gastric fundus and pylorus of sGCβ1his105phe mutant mice

Authors: Ingeborg Dhaese, Gwen Vanneste, Robrecht Thoonen, Peter Brouckaert and Romain Lefebvre

Citation: BMC Pharmacology 2007 7(Suppl 1):P15

Content type: Poster presentation Published on: 25 July 2007
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Transgenic mice with a NO-insensitive soluble guanylate cyclase

Authors: Peter Brouckaert, R Thoonen, Patrick Sips, Emmanuel Buys, E Rogge and Tino Hochepied

Citation: BMC Pharmacology 2007 7(Suppl 1):S16

Content type: Oral presentation Published on: 25 July 2007
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Reperfusion lung injury is attenuated by natriuretic peptide receptor antagonist in in-vivo mouse model

Authors: Jeffrey M Dodd-o, Maria L Hristopoulos, Jolanta Gutkowska, S Mukaddam-Daher, K Kibler, A Gonzalez and David B Pearse

Citation: BMC Pharmacology 2007 7(Suppl 1):P16

Content type: Poster presentation Published on: 25 July 2007
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Guanylyl cyclase-A mediated endothelial actions of natriuretic peptides are critically involved in postischemic reperfusion

Authors: Michaela Kuhn, Kristine Schwarz, Katharina Völker, Birgit Gaßner, Stepan Gambaryan, Hideo A Baba and Martin van Eickels

Citation: BMC Pharmacology 2007 7(Suppl 1):S17

Content type: Oral presentation Published on: 25 July 2007
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Chronic inhibition of cyclic GMP phosphodiesterase 5A may promote pressure overload-induced chamber dilatation in mice

Authors: Elisabeth Eder, Martin van Eickels, Stefan Frantz, Katharina Völker, Hideo A Baba and Michaela Kuhn

Citation: BMC Pharmacology 2007 7(Suppl 1):P17

Content type: Poster presentation Published on: 25 July 2007
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Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients

Authors: Vicente Felipo, Blanca Piedrafita, Amparo Urios, Miguel A Serra, A del Olmo, José M Rodrigo and Carmina Montoliu

Citation: BMC Pharmacology 2007 7(Suppl 1):P18

Content type: Poster presentation Published on: 25 July 2007
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Receptor guanylyl cyclase-G-deficient mice are protected against renal ischemia-reperfusion injury by preventing apoptosis and inflammation

Authors: Ruey-Bing Yang, Heng Lin, Ching-Feng Cheng, Hsin-Han Hou, Wei-Shiung Lian, Bambang Djoko, Ming-Tzu Tsai and Chien-Jui Cheng

Citation: BMC Pharmacology 2007 7(Suppl 1):S18

Content type: Oral presentation Published on: 25 July 2007
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New mouse models for the analysis of cGMP signalling

Authors: Robert Feil, Susanne Feil, Paul Franken, Yann Emmenegger, Mehdi Tafti, Karin Weindl, Sabine M Hölter, Wolfgang Wurst, Sonja Langmesser, Urs Albrecht, Michael Föller, Florian Lang, Silke Weber and Franz Hofmann

Citation: BMC Pharmacology 2007 7(Suppl 1):S19

Content type: Oral presentation Published on: 25 July 2007
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Effect of new sildenafil analogues in the rabbit isolated aorta

Authors: Haroldo A Flores Toque, Fernanda BM Priviero, Cleber E Teixeira, Edson Antunes and Gilberto de Nucci

Citation: BMC Pharmacology 2007 7(Suppl 1):P19

Content type: Poster presentation Published on: 25 July 2007
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A mouse (and chips) model for NO-activated guanylyl cyclase

Authors: John Garthwaite and Brijesh Roy

Citation: BMC Pharmacology 2007 7(Suppl 1):S20

Content type: Oral presentation Published on: 25 July 2007
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BAY 63–2521, an oral soluble guanylate cyclase stimulator, has a favourable safety profile and decreases peripheral vascular resistance in healthy male volunteers

Authors: Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann and Georg Wensing

Citation: BMC Pharmacology 2007 7(Suppl 1):P20

Content type: Poster presentation Published on: 25 July 2007
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Rapid monitoring of intracellular cGMP

Authors: Viacheslav O Nikolaev and Martin J Lohse

Citation: BMC Pharmacology 2007 7(Suppl 1):S21

Content type: Oral presentation Published on: 25 July 2007
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BAY 58–2667, a soluble guanylate cyclase activator, has a favourable safety profile and reduces peripheral vascular resistance in healthy male volunteers

Authors: Reiner Frey, Wolfgang Mück, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann and Georg Wensing

Citation: BMC Pharmacology 2007 7(Suppl 1):P21

Content type: Poster presentation Published on: 25 July 2007
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FlincGs: novel, non-FRET cGMP biosensors with nanomolar sensitivity for NO-induced signaling

Authors: Lydia WM Nausch and Wolfgang R Dostmann

Citation: BMC Pharmacology 2007 7(Suppl 1):S22

Content type: Oral presentation Published on: 25 July 2007
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Physiological and pathological effects of complete sGC deletion

Authors: Andreas Friebe, Dieter Groneberg, Peter König and Doris Koesling

Citation: BMC Pharmacology 2007 7(Suppl 1):P22

Content type: Poster presentation Published on: 25 July 2007
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cGMP compartments in cardiac myocytes

Authors: Rodolphe Fischmeister and Liliana Castro

Citation: BMC Pharmacology 2007 7(Suppl 1):S23

Content type: Oral presentation Published on: 25 July 2007
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Interstitial cells of Cajal in the urethra as effectors of the nitric oxide action through the cyclic GMP pathway

Authors: Angeles Garcia-Pascual, Maria Sancho, Gonzalo Costa and Domingo Triguero

Citation: BMC Pharmacology 2007 7(Suppl 1):P23

Content type: Poster presentation Published on: 25 July 2007
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Design and characterization of FRET-based cGMP indicators

Authors: Michael Russwurm, Florian Mullershausen, Andreas Friebe, Ronald Jäger, Corina Russwurm and Doris Koesling

Citation: BMC Pharmacology 2007 7(Suppl 1):S24

Content type: Oral presentation Published on: 25 July 2007
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Lack of NO-mediated NANC relaxation in mice deficient in NO-sensitive guanylyl cyclase

Authors: Dieter Groneberg, Doris Koesling and Andreas Friebe

Citation: BMC Pharmacology 2007 7(Suppl 1):P24

Content type: Poster presentation Published on: 25 July 2007
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Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities

Authors: Joseph A Beavo, Johannes L Bos, Elke Butt, Stein O Doskeland, Hans-Gottfried Genieser, Thomas R Hinds, Heiko Poppe, Holger Rehmann, Sergei D Rybalkin, Frank Schwede and Xiao-Bo Tang

Citation: BMC Pharmacology 2007 7(Suppl 1):S25

Content type: Oral presentation Published on: 25 July 2007
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Design and synthesis of the first NO- and haem-independent sGC activator BAY 58–2667 for the treatment of acute decompensated heart failure

Authors: Michael G Hahn, Cristina Alonso-Alija, Friederike Stoll, Markus Heil, Joachim Mittendorf, Karl-Heinz Schlemmer, Frank Wunder and Johannes-Peter Stasch

Citation: BMC Pharmacology 2007 7(Suppl 1):P25

Content type: Poster presentation Published on: 25 July 2007
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3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

BMC Pharmacology