Figure 6
From: A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen
RGS alignment. A) The structure of the RGS4 domain [3] with the cysteines highlighted. B) An alignment of the RGS proteins used in Figure 3 compared to the RGS4Δ51N construct. The RGS proteins are listed in order of inhibition by 5nd. The red residues are conserved and the blue are not. The stared residues are important for Gα interactions and the cysteines in RGS4 are boxed.