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Volume 7 Supplement 2

13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)

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Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment

BMC Pharmacology volume 7, Article number: A46 (2007) Cite this article

Objective

In our previous experiments a decrease of the MDMA-induced 5-HT syndrome (HTS) was observed following repeated administration of the dextrorotatory (d) enantiomer of MDMA. The aim of the present study was to examine how the dopamine agonist-induced stereotyped behaviour (SB) alters following single or repeated d-MDMA treatment.

Methods

Wistar male rats were treated with single or repeated (4 times with 2 hours intervals) doses (10 mg/kg) of d-MDMA. Three, 7 and 14 days later the intensity of d-MDMA-induced HTS and SB was examined. The SB-inducing effect of d-amphetamine (AM) and apomorphine (APO) was also checked.

Results

(1) Following repeated administration of d-MDMA the intensity of MDMA-induced HTS decreased while that of SB increased. (2) Single dose pretreatment with d-MDMA did not influence the d-MDMA-induced HTS but enhanced the SB. (3) The d-AM-induced SB also increased while the APO-induced SB did not change.

Conclusion

A single dose of d-MDMA, which, in contrast to the repeated treatment, did not alter the 5-HT-related behaviour, may already result in development of DA sensitization.

Acknowledgements

This work was supported by Hungarian grants OTKA K-60999 and ETT-441/2006.

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Authors and Affiliations

  1. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary

    Susanna Szelényi, Ágnes Bajnogel-Orosz, Julia Timár, Susanna Gyarmati, Melinda Sobor & Susanna Fürst

  2. National Institute of Pharmacy, Budapest, Hungary

    Melinda Sobor

  3. HAS-SE Neuropsychopharmacology Research Group, Budapest, Hungary

    Susanna Fürst

Authors
  1. Susanna Szelényi
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  2. Ágnes Bajnogel-Orosz
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  3. Julia Timár
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  4. Susanna Gyarmati
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  5. Melinda Sobor
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  6. Susanna Fürst
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Corresponding author

Correspondence to Julia Timár.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Szelényi, S., Bajnogel-Orosz, Á., Timár, J. et al. Changes in stereotyped behaviour following acute or repeated methylenedioxy-methamphetamine (MDMA) treatment. BMC Pharmacol 7 (Suppl 2), A46 (2007). https://doi.org/10.1186/1471-2210-7-S2-A46

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  • DOI: https://doi.org/10.1186/1471-2210-7-S2-A46

Keywords

BMC Pharmacology

ISSN: 1471-2210