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Volume 7 Supplement 2

13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)

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GPR55 is a novel cannabinoid receptor

BMC Pharmacology volume 7, Article number: A3 (2007) Cite this article

Cannabinoids exert their effects by binding to G protein-coupled receptors (GPCRs). To date, two cannabinoid receptors have been cloned. The cannabinoid CB1 receptor is one of the most abundant GPCRs in the central nervous system and plays an important role in pain transmission, feeding and the rewarding effects of cannabis, whereas the CB2 receptor is predominantly found in immune cells. However, some effects of cannabinoids (especially in the vascular system) could not be attributed to either CB1 or CB2 receptor function. Here we present GPR55 as a putative novel cannabinoid receptor, since GPR55 signals, binds to and internalizes in the presence of synthetic cannabinoid ligands.

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Authors and Affiliations

  1. Department of Experimental and Clinical Pharmacology, Medical University of Graz, Austria

    Nariman Balenga & Maria Waldhoer

  2. Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, UK

    Andrew J Irving

Authors
  1. Nariman Balenga
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  2. Andrew J Irving
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  3. Maria Waldhoer
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Corresponding author

Correspondence to Maria Waldhoer.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Balenga, N., Irving, A.J. & Waldhoer, M. GPR55 is a novel cannabinoid receptor. BMC Pharmacol 7 (Suppl 2), A3 (2007). https://doi.org/10.1186/1471-2210-7-S2-A3

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  • DOI: https://doi.org/10.1186/1471-2210-7-S2-A3

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BMC Pharmacology

ISSN: 1471-2210