Figure 2
From: In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate
Percentual distribution along time of the oleoyl-DHEA derived tritium label in plasma of Wistar rats (male: left column, female: right column) receiving a single gavage of oleoyl-DHEA (upper row) or DHEA (lower row). Black area: "lipophilic" zone of distribution of the label in a TLC system; dotted area: "intermediate" zone; white area: "hydrophilic" zone. Statistical significance (P < 0.05) of the differences between groups (2-way ANOVAs). For male rats the gavage type resulted in differences for hydrophilic and lipophilic fractions; in females only for the lipophilic. In Oleoyl-DHEA-treated rats, there were no sex-related differences; in DHEA-treated animals sex affected significantly all three fractions.