From: Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis
Variable | pK i | log (Ki Receptor 1/Ki Receptor 2) | ||
---|---|---|---|---|
 | 1st Principal Component | 2nd Principal Component | 1st Principal Component | 2nd Principal Component |
Haloperidol | -0.205 | -0.923 | -0.272 | -0.901 |
Clozapine | 0.796 | 0.260 | 0.780 | 0.356 |
LE300 | 0.775 | 0.629 | 0.921 | 0.354 |
LE400 | 0.955 | 0.222 | 0.983 | 0.122 |
LE403 | 0.488 | 0.868 | 0.290 | 0.933 |
LE404 | 0.410 | 0.886 | 0.395 | 0.893 |
LE410 | 0.739 | 0.568 | 0.840 | 0.433 |
LE420 | 0.829 | 0.549 | 0.873 | 0.474 |