From: Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis
Compound | pKi | |||||
---|---|---|---|---|---|---|
 | hD1 | hD2L | hD3 | hD4.4 | hD5 | h5HT2A |
Haloperidol | 6.55 ± 0.09 | 8.56 ± 0.05 | 8.00 ± 0.05 | 8.10 ± 0.04 | 7.50 ± 0.06 | 6.84 ± 0.12 |
Clozapine | 6.68 ± 0.03 | 6.60 ± 0.06 | 6.13 ± 0.05 | 6.93 ± 0.08 | 6.50 ± 0.08 | 8.23 ± 0.07 |
LE300 | 7.98 ± 0.06 | 7.19 ± 0.04 | 6.48 ± 0.04 | 6.46 ± 0.08 | 7.99 ± 0.05 | 9.65 ± 0.04 |
LE400 | 5.58 ± 0.16 | 5.90 ± 0.05 | 5.28 ± 0.07 | 4.79 ± 0.06 | 5.44 ± 0.07 | 6.86 ± 0.13 |
LE401 | 4.77 ± 0.25 | 5.06 ± 0.13 | 4.83 ± 0.16 | < 4a) | 4.79 ± 0.50 | < 4a) |
LE403 | 7.94 ± 0.06 | 6.43 ± 0.07 | 6.14 ± 0.10 | 6.26 ± 0.06 | 7.84 ± 0.05 | 8.40 ± 0.08 |
LE404 | 8.47 ± 0.10 | 7.10 ± 0.05 | 6.73 ± 0.06 | 7.23 ± 0.03 | 8.53 ± 0.09 | 8.79 ± 0.07 |
LE410 | 7.76 ± 0.04 | 7.54 ± 0.06 | 6.86 ± 0.07 | 6.32 ± 0.06 | 7.78 ± 0.10 | 8.40 ± 0.10 |
LE420 | 6.89 ± 0.07 | 6.64 ± 0.05 | 6.07 ± 0.06 | 5.83 ± 0.11 | 6.92 ± 0.04 | 7.97 ± 0.05 |