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Figure 5 | BMC Pharmacology

Figure 5

From: A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones

Figure 5

The effect of c.Lobo and c.Sl on cultured DRG neurones. A) Time course showing the action of c.Lobo (100 μg/mL) in three separate DRG neurones stimulated with 500 ms current step commands. Extracellular application of c.Lobo leads to an increase in the number of action potentials evoked relative to the control. After removal of the drug pipette, an increase in action potential number is followed by a steady decrease to basal levels. B) Voltage traces illustrating the effects that c.Lobo has on both action potential number and action potential shape. C) Voltage traces showing the inability of c.Sl to evoke a switch to multiple firing, followed by application of c.Lobo, which initiates multiple firing. For all records the DRG neurone was stimulated with depolarizing 600 pA step commands. Recovery is seen after removal of c.Lobo and upon further application multiple firing is once again evoked. In all cases the DRG neurones were held at -70 mV before stimulation. with 500 ms.

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BMC Pharmacology

ISSN: 1471-2210