Drug | Dose (μg/kg) | Mean arterial pressure (mmHg, n = 6) | Reduction due to drug | ||
---|---|---|---|---|---|
 |  | Before drug | After drug | Mean reduction |  |
Vehicle | 0.05 ml | 126.2 ± 2.8 | 110.0 ± 4.1 | 16.2 ± 1.4 | --- |
Reserpine | 0.25 | 138.3 ± 4.6 | 119.5 ± 4.2 | 18.8 ± 1.4NS | 2.6 |
 | 0.50 | 134.1 ± 5.5 | 91.2 ± 5.0 | 42.9 ± 0.9** | 26.5 |
 | 1 | 135.2 ± 4.7 | 80.5 ± 3.8 | 54.8 ± 1.6** | 38.6 |
 | 5 | 130.5 ± 5.1 | 69.0 ± 3.5 | 61.5 ± 2.8** | 45.3 |
 | 10 | 130.0 ± 4.2 | 58.7 ± 3.9 | 71.2 ± 1.3** | 55.0 |
 | 15 | 131.5 ± 5.1 | 41.1 ± 2.9 | 90.4 ± 3.1** | 74.2 |
Reserpine methonitrate equivalent to reserpine | 10 | 128.8 ± 6.4 | 90.0 ± 9.1 | 38.8 ± 3.6** | 22.6 |
 | 25 | 135.0 ± 8.5 | 73.0 ± 7.4 | 62.0 ± 2.8** | 45.8 |
 | 50 | 136.8 ± 5.3 | 42.5 ± 3.7 | 93.0 ± 8.0** | 76.8 |